| Singles competition |
| 1. #28 Georgia Drummy (DU) def. Andrea DiPalma (LOU) 3-6, 6-2, 1-0 (10-3) |
| 2. #8 Kelly Chen (DU) def. Nikolina Jovic (LOU) 6-3, 6-1 |
| 3. #29 Chloe Beck (DU) def. Raven Neely (LOU) 6-1, 6-3 |
| 4. #44 Margaryta Bilokin (DU) def. Chelsea Sawyer (LOU) 6-0, 6-4 |
| 5. #111 Meible Chi (DU) def. Rhea Verma (LOU) 5-7, 6-3, 1-0 (10-3) |
| 6. #95 Karolina Berankova (DU) def. Jelena Vujanic (LOU) 6-2, 7-5 |
| Doubles competition |
| 1. Meible Chi/Margaryta Bilokin (DU) def. Rhea Verma/Andrea DiPalma (LOU) 6-2 |
| 2. Chloe Beck/Karolina Berankova (DU) def. Raven Neely/Tatiana Simova (LOU) 6-1 |
| 3. Kelly Chen/Georgia Drummy (DU) def. Chelsea Sawyer/Dina Chaika (LOU) 6-2 |
| Match Notes |
| Louisville 5-4, 2-2 (ACC) |
| Duke 7-1, 2-0 (ACC); National ranking #11 |
| Order of finish: Doubles (3,1,2); Singles (3,2,4,6,1,5) |
| First match played outside in 2021 at Ambler Tennis Stadium |